Icy therapy spot treats cancer in the lung

Public release date: 14-Apr-2013
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Contact: Ellen Acconcia
eacconcia@sirweb.org
703-460-5582
Society of Interventional Radiology

Cryoablation: Interventional radiologists present results of research on a new minimally invasive treatment option for advanced cancers that have spread to lung tissue

NEW ORLEANS (April 14, 2013)Frozen balls of ice can safely kill cancerous tumors that have spread to the lungs, according to the first prospective multicenter trial of cryoablation. The results are being presented at the Society of Interventional Radiology's 38th Annual Scientific Meeting in New Orleans.

"Cryoablation has potential as a treatment for cancer that has spread to the lungs from other parts of the body and could prolong the lives of patients who are running out of options," said David A. Woodrum, M.D., Ph.D., an author of the study and interventional radiologist at the Mayo Clinic in Rochester, Minn. "We may not be able to cure the cancer, but with cryoablation we can at least slow it down significantly and allow patients to enjoy greater quality of life longer," he added. Metastatic lung disease is difficult to treat and often signals a poor prognosis for patients.

In the initial results of the study, called the ECLIPSE trial (Evaluating Cryoablation of Metastatic Lung/Pleura Tumors in PatientsSafety and Efficacy), 22 subjects with a total of 36 tumors were treated with 27 cryoablation sessions. Cryoablation was 100 percent effective in killing those tumors at three-month follow-up. Follow-up at six months on 5 of the 22 patients (23 percent) showed the treated tumors to still be dead. Cryoablation is performed by an interventional radiologist using a small needle-like probe guided through a nick in the skin to cancerous tumors inside the lung under medical imaging guidance. These tumors have spreador metastasizedto the lung from primary cancers in other areas of the body. Once in position, the tip of the instrument is cooled with gas to as low as minus 100 degrees Celsius. The resulting halo of ice crystals can destroy cancer by interrupting its cellular function, protecting nearby healthy, delicate lung tissue. Lung cryoablation has been promising in part due to the low periprocedural morbidity.

"Most of these patients can go home the day after their cryoablation treatment and resume their normal activities," Woodrum said, noting that researchers plan to continue to follow patients for up to five years. While cryoablation is being developed for the treatment of metastatic lung cancer, the future looks brighter for individuals who once had nowhere else to turn, said Woodrum, who was assisted in research by Frank Nichols, M.D. and Matthew R. Callstrom, M.D.

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More information about the Society of Interventional Radiology, interventional radiologists and minimally invasive treatments can be found online at http://www.SIRweb.org.

Abstract 33: "Evaluating Cryoablation of Metastatic Lung/Pleura Tumors in PatientsSafety and Efficacy (ECLIPSE)," T. de Baere, G. Farouil, Institut de Cancerologie Gustave Roussy, Villejuif Cedex, France; D.A. Woodrum, Mayo Clinic, Rochester, Minn.; F. Abtin, University of CaliforniaLos Angeles, Los Angeles, Calif.; P. Littrup, Karmanos Cancer Institute, Detroit, Mich., SIR 38th Annual Scientific Meeting, April 13-18, 2013. This abstract can be found at http://www.SIRmeeting.org.

About the Society of Interventional Radiology

Interventional radiologists are physicians who specialize in minimally invasive, targeted treatments. They offer the most in-depth knowledge of the least invasive treatments available coupled with diagnostic and clinical experience across all specialties. They use X-ray, MRI and other imaging to advance a catheter in the body, such as in an artery, to treat at the source of the disease internally. As the inventors of angioplasty and the catheter-delivered stent, which were first used in the legs to treat peripheral arterial disease, interventional radiologists pioneered minimally invasive modern medicine. Today, interventional oncology is a growing specialty area of interventional radiology. Interventional radiologists can deliver treatments for cancer directly to the tumor without significant side effects or damage to nearby normal tissue.

Many conditions that once required surgery can be treated less invasively by interventional radiologists. Interventional radiology treatments offer less risk, less pain and less recovery time compared to open surgery. This year, SIR celebrates 40 years of innovation and advances in interventional radiology. Visit http://www.SIRweb.org.

The Society of Interventional Radiology is holding its 38th Annual Scientific Meeting April 13-18 at the Ernest N. Morial Convention Center, New Orleans. The theme of the meeting is 'IR Reaching Out,' adopted to illustrate the many ways the Annual Scientific Meeting provides valuable education to attendees with a broad range of diverse clinical interests and practice settings.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 14-Apr-2013
[ | E-mail | Share ]

Contact: Ellen Acconcia
eacconcia@sirweb.org
703-460-5582
Society of Interventional Radiology

Cryoablation: Interventional radiologists present results of research on a new minimally invasive treatment option for advanced cancers that have spread to lung tissue

NEW ORLEANS (April 14, 2013)Frozen balls of ice can safely kill cancerous tumors that have spread to the lungs, according to the first prospective multicenter trial of cryoablation. The results are being presented at the Society of Interventional Radiology's 38th Annual Scientific Meeting in New Orleans.

"Cryoablation has potential as a treatment for cancer that has spread to the lungs from other parts of the body and could prolong the lives of patients who are running out of options," said David A. Woodrum, M.D., Ph.D., an author of the study and interventional radiologist at the Mayo Clinic in Rochester, Minn. "We may not be able to cure the cancer, but with cryoablation we can at least slow it down significantly and allow patients to enjoy greater quality of life longer," he added. Metastatic lung disease is difficult to treat and often signals a poor prognosis for patients.

In the initial results of the study, called the ECLIPSE trial (Evaluating Cryoablation of Metastatic Lung/Pleura Tumors in PatientsSafety and Efficacy), 22 subjects with a total of 36 tumors were treated with 27 cryoablation sessions. Cryoablation was 100 percent effective in killing those tumors at three-month follow-up. Follow-up at six months on 5 of the 22 patients (23 percent) showed the treated tumors to still be dead. Cryoablation is performed by an interventional radiologist using a small needle-like probe guided through a nick in the skin to cancerous tumors inside the lung under medical imaging guidance. These tumors have spreador metastasizedto the lung from primary cancers in other areas of the body. Once in position, the tip of the instrument is cooled with gas to as low as minus 100 degrees Celsius. The resulting halo of ice crystals can destroy cancer by interrupting its cellular function, protecting nearby healthy, delicate lung tissue. Lung cryoablation has been promising in part due to the low periprocedural morbidity.

"Most of these patients can go home the day after their cryoablation treatment and resume their normal activities," Woodrum said, noting that researchers plan to continue to follow patients for up to five years. While cryoablation is being developed for the treatment of metastatic lung cancer, the future looks brighter for individuals who once had nowhere else to turn, said Woodrum, who was assisted in research by Frank Nichols, M.D. and Matthew R. Callstrom, M.D.

###

More information about the Society of Interventional Radiology, interventional radiologists and minimally invasive treatments can be found online at http://www.SIRweb.org.

Abstract 33: "Evaluating Cryoablation of Metastatic Lung/Pleura Tumors in PatientsSafety and Efficacy (ECLIPSE)," T. de Baere, G. Farouil, Institut de Cancerologie Gustave Roussy, Villejuif Cedex, France; D.A. Woodrum, Mayo Clinic, Rochester, Minn.; F. Abtin, University of CaliforniaLos Angeles, Los Angeles, Calif.; P. Littrup, Karmanos Cancer Institute, Detroit, Mich., SIR 38th Annual Scientific Meeting, April 13-18, 2013. This abstract can be found at http://www.SIRmeeting.org.

About the Society of Interventional Radiology

Interventional radiologists are physicians who specialize in minimally invasive, targeted treatments. They offer the most in-depth knowledge of the least invasive treatments available coupled with diagnostic and clinical experience across all specialties. They use X-ray, MRI and other imaging to advance a catheter in the body, such as in an artery, to treat at the source of the disease internally. As the inventors of angioplasty and the catheter-delivered stent, which were first used in the legs to treat peripheral arterial disease, interventional radiologists pioneered minimally invasive modern medicine. Today, interventional oncology is a growing specialty area of interventional radiology. Interventional radiologists can deliver treatments for cancer directly to the tumor without significant side effects or damage to nearby normal tissue.

Many conditions that once required surgery can be treated less invasively by interventional radiologists. Interventional radiology treatments offer less risk, less pain and less recovery time compared to open surgery. This year, SIR celebrates 40 years of innovation and advances in interventional radiology. Visit http://www.SIRweb.org.

The Society of Interventional Radiology is holding its 38th Annual Scientific Meeting April 13-18 at the Ernest N. Morial Convention Center, New Orleans. The theme of the meeting is 'IR Reaching Out,' adopted to illustrate the many ways the Annual Scientific Meeting provides valuable education to attendees with a broad range of diverse clinical interests and practice settings.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/soir-its040713.php

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Hilary Koprowski, Pioneering Polio Vaccine Developer, Dies At 96

PHILADELPHIA -- Dr. Hilary Koprowski, a pioneering virologist who developed the first successful oral vaccination for polio, died this week at his suburban Philadelphia home. He was 96.

Although not as well-known as fellow researchers Jonas Salk and Albert Sabin, Koprowski's 1950 clinical trial was the first to show it was possible to vaccinate against polio, the crippling and sometimes fatal disease that's now all but eradicated.

Koprowski's son, Christopher, said Saturday his father liked the scientific recognition his work received without the celebrity of Salk and Sabin.

"He enjoyed not having his scientific work disrupted," said Christopher Koprowski, chief of radiation oncology at Christiana Care Health System in Wilmington, Del. "Not that he was a modest individual, mind you."

Christopher Koprowski said his father had been sick for several months before dying Thursday in the same Wynnewood home he'd lived in since 1957.

Hilary Koprowski self-administered the live-virus oral vaccine he developed before the 1950 trial ? about two years before Salk's injectable version using a dead form of the virus began testing with the backing of the National Foundation for Infantile Paralysis, now the March of Dimes.

Sabin, who Koprowski's son said sometimes collaborated with his father, was the first to get the more-effective oral version, which didn't require boosters, licensed for use in the U.S.

Koprowski went on to be the director of The Wistar Institute in Philadelphia from 1957 to 1991. Under his leadership, the independent research institution developed a rubella vaccine that helped eradicate the disease in much of the world, Wistar officials said. It was during that time the institute also developed a more effective rabies vaccine.

A talented musician, the Polish-born Koprowski was a penniless immigrant in Rio de Janeiro making money teaching piano before hooking up with a lab there and eventually moving to the United States, his son said.

"He was a great dad. He was colorful, charismatic," Christopher Koprowski said. "He's still the most brilliant person I've ever met."

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/04/14/hilary-koprowski-dead_n_3078365.html

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Telus reportedly in talks to buy Mobilicity, spectrum likely to be the prize

Canadians have been enjoying a minor renaissance in wireless competition since its AWS auction allowed a slew of smaller carriers to join the fray. Unfortunately, that diversity might be shrinking soon. The Globe and Mail reportedly has documents showing that Telus has been in active talks to buy Mobilicity through a share buyout deal. While the apparent leak doesn't mention the exact motivations, it's thought to be a spectrum grab when LTE on major Canadian carriers primarily leans on the very AWS frequencies that Mobilicity also uses for its 3G service. Neither Telus nor Mobilicity is commenting, although we'd note that there may be a few roadblocks (however temporary) if the scoop is accurate. Rules meant to preserve competition will prevent Telus from buying any newcomers' spectrum until early 2014, and Mobilicity left the Canadian Wireless Telecommunications Association just this week while accusing the industry group of being a puppet for bigger networks like Telus. If negotiations are real and still in progress, there could be some very awkward meetings ahead.

[Image credit: Andrew Currie, Flickr]

Filed under: Cellphones, Wireless, Mobile

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Via: MobileSyrup (1), (2)

Source: The Globe and Mail

Source: http://www.engadget.com/2013/04/13/telus-reportedly-in-talks-to-buy-mobilicity/

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Tesla Should Make Sergey Brin's Model S Makeover A Standard Option

Google co-founder Sergey Brin appears to have been pranked by Google employees, according to info shared on the Tesla Motors Club forum. This image of the Google bigwig's fancy Tesla Model S roadster, with some aftermarket additions, popped up today on Twitter. Note the sweet "Chrome" rims it's rolling on, if you can pull your eyes away from the hot pink color scheme, long beautiful eyelashes and Batman iconography.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/29rkTVIdS8g/

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What Advantages Does an Invisible Hearing Aid Give You? | Your ...

By Emily Steves

There are many advantages associated with using invisible hearing aids, which can help you to enjoy improved comfort alongside the best quality digital programming. Invisible hearing aids can be fitted inside the ear canal, and cannot be seen by observers. As well as this discreet advantage, invisible hearing aids make use of high tech hearing technology, and are available in several specialist brands; it?s also worth remembering, though, that some wearers may not be suitable for invisible hearing aids due to the size of their ear canal.

An invisible hearing aid is designed to fit within the ear canal, and is fitted to your particular hearing needs; as with other digital hearing aids, invisible hearing aids can be programmed to filter out different kinds of sounds, and can be set up to deliver the best sound for phone conversations and crowds.

Invisible hearing aids are typically fitted much closer to your ear drum than other hearing aids that clip around your ear. At the same time, invisible hearing aids are built to resist water and wax, but not intensive activities like swimming or being underwater in the bath.

One of the main advantages, then, of wearing invisible hearing aids is that you can reduce any anxiety about wearing a visible hearing aid in public; while now common, many younger people and children are still uncomfortable about wearing a hearing aid. Invisible hearing aids consequently provide a solution that allows people to enjoy enhanced hearing without having to worry about being judged ? again, hearing aids have advanced to the point where designs and visibility mean that they be comfortably worn without being self conscious.

There are many different invisible hearing aid brands that can be tailored to your hearing loss. Among these brands, Phonak hearing aids use cutting edge technology to enhance your hearing, and feature advanced settings such as sound-flow and whistle-block. While standard hearing aids can achieve much of the same effects, Phonic?s invisible hearing aids are designed to be small and easy to wear without noticing them.

One of the main advantages, then, of wearing invisible hearing aids is that you can reduce any anxiety about wearing a visible hearing aid in public?..

Other popular invisible hearing aid brands include those made by Starkey SoundLens ? these invisible hearing aids can be worn within your ear canal, and can be set up to cut out whistling and any other forms of interference. In the same way, brands like the Siemens iMini include features like feedback stopping, directional hearing, speech enhancement, and noise reduction when you?re out in public or in busy restaurants and bars.

When looking for an invisible hearing aid, it?s crucial to get a consultation with a trained audiologist, who can assess your type of hearing loss, and whether an invisible hearing aid is right for you. Unfortunately, some people do not have wide enough ear canals to have invisible hearing aids fitted, so make sure that you get a full consultation before making a decision.

It?s also important to ensure that your service includes aftercare, whereby an audiologist can deal with everything from discomfort when the hearing aid is being worn, through to reprogramming it to adjust to your hearing.

- Blogger Emily Steves suffers from hearing loss. She likes sharing her experiences and thoughts about many different invisible hearing aid brands. She firmly believes that these can help you understand the issues of hearing loss more efficiently.

Source: http://www.lensaunders.com/wp/what-advantages-does-an-invisible-hearing-aid-give-you/

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Japan central bank revamps policy to boost economy

TOKYO (AP) ? Japan is taking aggressive action to lift consumer prices, encourage borrowing and help pull the world's third-largest economy out of a long slump.

Like the U.S. Federal Reserve, Japan's central bank plans to flood its financial system with more money ? its most far-reaching step to date to get consumers and companies to borrow and spend.

The Bank of Japan's action will also drive down the value of the yen. A cheaper currency will make Japanese goods ? from Toyota cars to Sony TVs ? less costly for Americans and other foreigners. And it will make U.S. and other exports more expensive in Japan.

The move comes as major central banks around the world are acting to stimulate their economies. On Thursday, European Central Bank President Mario Draghi said the ECB is considering doing more to shore up the ailing economy of the euro alliance. The ECB left its benchmark interest rate unchanged at 0.75 percent, but Draghi said an interest rate cut was discussed Thursday.

Draghi also said the central bank is considering "various tools" beyond lower rates in case Europe's economy needs more help.

And the U.S. Fed has said it expects to keep short-term rates at record lows at least until unemployment falls to 6.5 percent from the current 7.7 percent. The Fed also plans to continue buying $85 billion a month in bonds indefinitely to keep long-term borrowing costs down.

"The central banks are being more activist than we've seen in decades," said Timothy Duy, an economist at the University of Oregon. "One central bank after another has to do more because economies aren't improving as fast as would have been expected."

Dan Akerson, CEO of General Motors Co., told CNBC that he feared the Bank of Japan's policies would give Japanese automakers a price advantage over GM in the United States.

"They're an export economy," Akerson said. "You have to be suspicious of what they're doing and why."

But many economists say the rest of the world will benefit, too: A faster-growing Japan will buy more products and services from the United States, China and Europe, helping boost their economies.

"We could see some faster and sustainable growth now in Japan," said Bernard Baumohl, chief global economist at the Economic Outlook Group. "That will obviously help the global economy."

Japan's economy has been sputtering for two decades. Last year, weak consumer spending kept prices flat. The Bank of Japan hopes to increase inflation to 2 percent within about two years. Economists say Japanese consumers will start spending if they know prices are going rise.

Eswar Prasad, an economist at Cornell University, cautioned that Japan needs more than easy-money policies to repair its economy. It needs to reduce its debts and reform policies that protect weak firms from competition and undercut the country's productivity.

"Japan would no longer be a drag on the global economic recovery if it had stronger domestic demand and positive inflation," Prasad said. "However, it is far from clear that the Bank of Japan's actions will be able to deliver these positive outcomes in the absence of broader structural reforms that are essential to revive Japan's productivity and competitiveness. "

Critics also say that without wage increases to match the price hikes, many consumers may be even less willing to spend.

"The new BOJ's willingness to experiment should be welcomed," said Uri Dadush, director of the economics program at the Carnegie Endowment for International Peace. "But they are also inevitably wading into unknown waters. There is no certainty that the new approach will work."

Baumohl added that BOJ's move could backfire if other countries deliberately push down the value of their currencies to regain a price edge for their exports.

"It does increase the risk of other countries taking similar moves in what they perceive as a currency war," he said.

In its announcement, the Bank of Japan said it plans to buy more than $530 billion a year in government bonds. BOJ governor Haruhiko Kuroda described the scale of monetary stimulus as "large beyond reason," but said the inflation target would remain out of reach if the central bank stuck to incremental steps.

"We'll adjust without hesitation if need be, while monitoring economic and price conditions," he said.

The Bank of Japan said it intends to "drastically change the expectations of markets and economic entities."

Since taking power late last year, Prime Minister Shinzo Abe's administration has pursued an aggressive stimulus program of government spending, monetary easing and planned reforms aimed at improving Japan's competitiveness.

On Thursday, Japanese stocks jumped and the yen sank after the central bank's announcement. The yen weakened 3 percent against the dollar, to 95.94 yen, while Tokyo's Nikkei stock index rose 2.2 percent to 12,634.54.

U.S.-listed shares of Japanese automakers rose sharply, reflecting the belief that a weaker yen would make Japanese vehicles cheaper in markets outside Japan. The U.S. shares of Toyota rose $4.43, or 4.4 percent, to $105.31, Honda's rose $1.93, or 5.2 percent, to $39.13 and the Nissan's rose 84 cents, 4.5 percent, to $19.66.

"By committing today to meet a 2 percent inflation target in two years, Gov. Kuroda can justifiably claim to have set the Bank of Japan on a new path," said Mark Williams of Capital Economics.

Kuroda has vowed to do what he must to meet the inflation target within two years. Thursday's decision after a two-day policy meeting makes that central bank policy.

Politically, the policy shift is a coup for Abe, whose Liberal Democratic Party needs to make headway in reviving the economy before an upper house parliamentary election in July. The LDP is hoping for a strong-enough mandate to push ahead with other items on their wish list, such as politically difficult economic and educational reforms and changes to the constitution to give Japan's military a higher profile.

Economy minister Akira Amari, who attended the policy meeting, praised Kuroda, giving him "very high marks,"

More aggressive monetary easing is a top priority, along with increased public spending to help perk up demand and reforms to make the economy more competitive in the long-run.

Abe had accused Kuroda's predecessor Masaaki Shirakawa, who stepped down on March 19, of balking at undertaking bold enough monetary easing to get the economy back on track. The steps announced Thursday under the first policy meeting chaired by Kuroda exceeded expectations in that regard.

"The first step is to get out of deflation and get a much higher nominal growth rate," Kozo Yamamoto, a senior lawmaker in Abe's Liberal Democratic Party, said Wednesday. A doubling of the money supply was needed to achieve that aim, he said.

The BOJ's policy reforms appear to be a major concession to government demands, despite the bank's ostensible autonomy.

The bank kept the benchmark rate at 0.1 percent. But instead of carrying out money market operations to meet interest rate targets that have long remained near zero, the central bank will focus on the monetary base, or total amount of cash in circulation and bank reserves, raising it by 60 trillion yen to 70 trillion yen ($637 billion to $744 billion) a year. The monetary base stood at 138 trillion yen ($1.45 trillion) at the end of 2012.

The idea is that increasing the amount of cash in circulation will inflate prices, including for assets, encouraging more spending by those who own shares and property.

"If prices don't go up, wages don't go up. If people believe prices will be higher six months from now, then they will believe it's best to buy now rather than later," Abe said in a parliamentary debate Tuesday.

___

Wiseman contributed from Washington. AP Auto Writer Tom Krisher contributed from Detroit.

Source: http://news.yahoo.com/japan-central-bank-revamps-policy-boost-economy-081553143--finance.html

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Coronary heart disease increases with body mass index, as well as with age: study

Apr. 2, 2013 ? Coronary heart disease (CHD) increases with body mass index (BMI), as well as with age, finds an article published in BioMed Central's open access journal BMC Medicine. The research from the Million Women Study indicates that increased weight increases risk of CHD equivalent to that caused by getting older.

Researchers from the University of Oxford followed the health of 1.2 million women from England and Scotland for (on average) almost a decade. Analysis of the data showed that the occurrence of CHD increases with BMI so that every 5 unit increase in BMI, calculated as weight/height2, increases incidence by 23%, which is equivalent to the risk conferred by getting older by 2.5 years.

The results showed that one in eleven lean middle aged women (with an average BMI of 21) will be admitted to hospital or will have died from CHD between the ages of 55 to 74. This risk progressively increases with BMI, and it reaches one in six, for obese women (with an average BMI of 34).

Dr Dexter Canoy, who led this study explained, "The risk of developing CHD increases even with small incremental increases in BMI, and this is seen not only in the heaviest but also in women who are not usually considered obese. Small changes in BMI, together with leading a healthy lifestyle by not smoking, avoiding excess alcohol consumption, and being physically active could potentially prevent the occurrence of CHD for a large number of people in the population.

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The above story is reprinted from materials provided by BioMed Central Limited, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F. Lucy Wright, Jane Green, Gillian Reeves, Valerie Beral, Million Women Study Collaborators. Body mass index and incident coronary heart disease in women: a population-based prospective study. BMC Medicine, 2013; 11 (1): 87 DOI: 10.1186/1741-7015-11-87

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/g2t_B_s_qBg/130402091303.htm

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